Company
Vasotop
Vasotop is an ACE inhibitor – a drug used to treat heart failure in dogs. Vasotop works in two ways, to ease the load on the heart and to reverse some of the damage caused by heart failure. The active ingredient in Vasotop is ramipril.ACE inhibitors don’t only act to reduce vascular resistance through vasodilation, they also need to act locally to inhibit some of the degenerative changes which occur in the heart muscle, blood vessel walls and kidneys as heart disease progresses. Vasotop (ramipril) is a highly lipophilic ACE inhibitor which has been shown to inhibit ACE at both the systemic and local level. Ramipril has been shown to induce the regression of existing myocardial hypertrophy1, to reduce smooth muscle cell proliferation in blood vessel walls2, and to increase renal blood flow3.
1McDonald et al (1995) Circulation 91, 2043-48
2Straeter-Knowlen et al (1999) Am J Physiol 277, H1924-30
3Omosu (1992) Japanese J Nephrol 34,
883-94
Vasotop 1.25: white, oblong tablets half scored on one side. Each tablet contains 1.25mg Ramipril PhEur.
Vasotop 2.5: yellow, oblong tablets half scored on one side. Each tablet contains 2.5mg Ramipril PhEur and 0.1mg yellow ferric oxide (E172).
Vasotop 5: red, oblong tablets half scored on one side. Each tablet contains 5mg Ramipril PhEur and 0.05mg red ferric oxide (E172).
For uses, dosage, contra-indications and warnings, see datasheet. Vasotop may only be prescribed and administered by your veterinary surgeon from whom advice should be sought. Further information is available on request.